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Dr. Ravi Vijayvargia has published over 28 research papers in high-impact international journals including eLife, Human Molecular Genetics, Structure, Journal of Biomolecular Structure & Dynamics, and many more reflecting the broad relevance and scientific merit of his work in neurodegeneration, protein misfolding, and structural biology.
Research Articles
Research Articles
Recent
Recent
R Dabhi, R Mehta, J Paneri, D Kakadiya, A Shah, S Singh, R Vijayvargia
Indian Journal of Biochemistry and Biophysics (IJBB), Volume 60, Issue 9 (741-749), 2023.
Y Lee, H Kim, D Barker, R Vijayvargia, RS Atwal, H Specht, H Keshishian
Human Molecular Genetics, Volume 32, Issue 1, 1 January 2023, Pages 30–45, https://doi.org/10.1093/hmg/ddac165
Most Cited
Most Cited
R Vijayvargia, R Epand, A Leitner, TY Jung, B Shin.... (2016)
M Belakavadi, PK Pandey, R Vijayvargia, JD Fondell
Molecular and cellular biology ( 3932-3942), 2008.
More....
PROJECTS
PROJECTS
Recent
Recent
Development of ELISA and lateral flow based high sensitivity rapid immunoassays for diagnosis and prognosis of common autoimmune diseases.
(2023-2026) Gujarat State Biotechnology Mission (GSBTM)
Deciphering the role of secretome in non-cell autonomous disease pathogenesis towards therapeutic intervention for Huntington’s Disease.
(2023-2026) Indian Council for Medical Research (ICMR)
This project investigates the role of the Huntington’s disease (HD) secretome in mediating non-cell autonomous pathogenesis by identifying its molecular components and assessing their impact on immune activation and cellular stress pathways, aiming to uncover novel therapeutic targets.
Completed
Completed
A combinatorial approach to target dysregulated pathways of Huntington’s Disease using small molecules.
(2021-2024) Indian Council for Medical Research (ICMR)
Development of aptamer based high sensitivity assays for detection of SARS CoV-2 antibodies.
(2021-2023) Gujarat State Biotechnology Mission (GSBTM)
The objective of the project was to develop a highly sensitive and cost-effective serological diagnostic platform, comprising ELISA and lateral flow assay kits, for the detection of anti-SARS-CoV-2 antibodies in human serum. As a critical step, the spike (S) protein of SARS-CoV-2 was successfully cloned, expressed, and purified, enabling its incorporation as the target antigen in both assay systems for robust immunodetection.
Huntingtin phosphorylation as a target for development of novel therapeutics for Huntington’s Disease.
(2017- 2020) SERB
Project investigate how global phosphorylation modulates mutant huntingtin’s interaction with PRC2 and its histone methyltransferase activity. Our work explores the interplay between polyQ expansion, phosphorylation, and epigenetic regulation in Huntington’s disease.
Molecular Investigation to determine prevalence of Huntington’s Disease in patients with motor symptoms.
(2014-2017) Research and Consultancy Cell, The M.S. University of Baroda
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